نام آوران سیستان به ترتیب حروف الفبا

رضا شیخ نژاد

نام:             رضا

نام خانوادگی:    شیخ نژاد

محل تولد:    زاهدان

تاریخ تولد:  27 دی 1330

دیپلم:       دبیرستان تمدن زاهدان

لیسانس:  دانشسرایعالی تهران

دکتری:       بیوشیمی از دانشگاه ایالتی جورجیا-آمریکا

فوق دکتری:   فیزیولوژی سلولی از دانشکده پزشکی دانشگاه ایالتی وین-دیترویت میشیگان

تخصص:    بیولوژی مولکولی تحقیقات دارویی سرطان

سابقه کار:   مرکز تحقیقات سرطان میشیگان

بازگشت به ایران:1387 شمسی

محل کار:شرکت تحقیقاتی مهندسی توفیق دارو-تهران

نوع تحقیق:   ساخت داروهای ضد سرطان

مقالات:       بیش از 30 مقاله و اختراع ثبت شده­ی بین المللی

کتاب:        1.  سرطان چیست؟

         2.  روانشناسی سرطان

ایمیل:       این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید

 
Sheikhnejad, Reza
Email: این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید


Education:

University of Teacher Education     Tehran/Iran    B.S.    1974        Biology
Western Carolina University, NC/ USA        M.S.    1981        Biology
University of Georgia, Athens, GA/USA         Ph.D.    1985        Biochemistry
 

Awards, Fellowships, Grants:

NIH Postdoctoral Fellowship award            1986     Cell Physiology
American Cancer Society Institutional award        1994
Inventor of the year, second place/Life Science        1997
European Association for Cancer Research Member,   2011

Positions Held:

1985-1986    Postdoctoral Trainee, University of Georgia Department of Biochemistry, Athens, Georgia
1986-1988    Postdoctoral Fellow, Wayne State School of Medicine, Department
of Physiology, Detroit, Michigan.
1988-1994    Assistant Member, Karmanos Cancer Institute, Detroit, Michigan.
1994-1997    Research Associate, Wayne State School of Medicine, Department of Radiation Oncology, Detroit, Michigan
1997-2001    Scientific Director, Anti-Gene Therapeutics Inc. Ann Arbor, Michigan
2001-2003    Scientific Director, SenseGene Therapeutics Inc. Kalamazoo Michigan
2005-Present Consultant and shareholder, ProNAi Therapeutics, Inc
Kalamazoo, Michigan
2008-Present Program Director, Tofigh Daru (TODACO), Tehran/Iran


Patents &Publications:


•    Sheikhnejad et al. “Methods and Compositions for   Cancer Therapy” US/Patent No: 7,807,647 B2 Issued Oct. 5, 2010

•    Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 7,524,827B2 Apr. 28, Issued 2009

•    Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 7,498,315B2, Issued Mar.3, 2009

•    Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2008/0152700 A1, Issued  Jun. 26, 2008

•    Sheikhnejad et al. “Methods and Compositions for   Cancer Therapy” US/Patent No: 2007/0213285 A1, Issued Sep. 13, 2007

•    Sheikhnejad G et al. “Methods and Compositions for The Inhibition of Gene Expression”   L80003601CA/ CANADA Pending, 2007  

•    Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2006/0229267 A1, Issued  Oct. 12, 2006

•    Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2006/0198828 A1, Issued  Sep. 7, 2006

•    Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2006/0135455 A1, Issued  Jun. 22, 2006

•    Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2005/0287667 A1, Issued  Dec. 29, 2005

•    Christman, Judith K., Elkhorn, Sheikhnejad, Gholamreza “Substrate for den Nachweis von 5-C-DNS Methyltransferase von Säugetiere” Europäischen Patentschrift, EP 0756008 B1, DE 696 24 761 T2, Issued 11, 9, 2003

•    Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase”  European Patent No:, EP 0756 008 B1, Issued 13.11.2002

•    Sheikhnejad, Gholamreza, “Compositions and Methods of Inhibiting Certain Genes” International Patent Publication Number:  WO 99/24560, Published Date: 20 May 1999

•    Sheikhnejad, Gholamreza,  “Ras Antisense Inhibition”  Patent Number: US 5874416, published: Feb. 23, 1999

•    Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase”  European Patent No:, EP 0756 008 A3, Issued 07.10.1998


•    Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase”  European Patent No:, EP 0756 008 A2, Issued 29.01.1997

•    Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase”  US Patent No:, 5,652,105, Issued Jul. 29, 1997
        
•    Marquez VE, Goddard A, Alvarez E, Ford H. Jr., Christman JK, Sheikhnejad G, Brank A, Marasco CJ, Sufrin JR, O’Gara M, Cheng X. “Oligonucleotides containing 5,6-dihydro-5-azacytosine at CpG sites can produce potent inhibition of DNA cytosine-C5-methyltransferase without covalently binding to the enzyme” Antisense & Nucleic Acid Drug Development, 9(4):415-421, (1999)

•    Sheikhnejad G, Brank A, Christman JK, Goddard A, Alvarez E, Ford H. Jr Marquez VE, Marasco CJ, Sufrin JR, O’Gara M, Cheng X. Mechanism of Inhibition of (cytosine-C5)-Methyltransferase by Oligonucleotides containing 5,6-dihydro-5-azacytosine. J Mol Biol; 285 (5): 2021-34, (1999)
 
•    Christman JK, Sheikhnejad G, Marasco CJ, Sufrin JR, 5-methyl-2-deoxycytidine in single stranded DNA can act in cis to signal de novo DNA methylation. Proc Natl Acad Sci (PNAS),; 92: 7347-7351,  (1995)

•    Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E. Methyl-Deficiency, DNA methylation and cancer studies on the reversibility of the effects of a Lipotrope Deficient Diet. J. Nutr. Biochem.; 4: 672-680, (1993)

•    Christman JK, Chen L, Sheikhnejad G, Dizik M, Abileah S, Wainfan E. Reversibility of Changes in Nucleic Acid Methylation and Gene Expression induced by Severe Dietary Methyl Deficiency. Carcinogenesis; 14: 551-557,  (1993)

•    Christman JK, Chen L, Sheikhnejad G, Dizik M, Wainfan E. A possible link between dietary methyl deficiency and hepatocarcinogenesis. In: The Role of Nutrients in Cancer treatment, Report of the 9th Ross Conference on Medical Research; 60-65, (1991)

•    Wainfan E, Dizik M, Sheikhnejad G, and Christman JK. Rapid and Reversible Changes in DNA Methylation and Gene Expression in Liver of Rats Fed Cancer Promoting Methyl-Deficient Diets.  The 6th Sardinian International Meeting in Chemical Carcinogenesis; (1991)

•    Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E. Increased rat Liver DNA and tRNA Methyltransferase Activities in Response to Feeding of Methyl-Deficient Diets. Proceedings of American Association for Cancer Research; 32: 143,  (1990)

•    Dizik M, Sheikhnejad G, and Christman JK. Early Changes in Nucleic Acid Methylation and Gene Expression in Livers of Rats Fed Cancer Promoting Methyl-Deficient Diets. FASEB; 4510 , (1990)

•    Dizik M, Wainfan E, Sheikhnejad G, and Christman JK. Rapid and Reversible Changes in DNA Methylation and Gene Expression in Liver of Rats Fed Cancer Promoting Methyl-Deficient Diets. Proceedings of American Association for Cancer Research; 32: 141, (1990)

•    Sheikhnejad G. Polasek, D.M. and Yingst, D.R. Purification of an Inhibitor of Ca-ATPase from Human Red Blood Cells. J. General Physiology, Boston, MA;  (1988)

•    Srivastava PN, Sheikhnejad G, Hosken FR, Malter H and Brackett M. Inhibition of Fertilization of Rabbit Ova in vitro by a Polyclonal Antibody  to the Inner-Acrosomal Membrane of Rabbit Sperm. J. Exp. Zoology; 238: 99-102,  (1986)

•    Sheikhnejad G and Srivastava PN.  Localization of Antigens on the Inner-Acrosomal Membrane of Rabbit Spermatozoa by Immuno-Fluorescense labeling. Gamete Research; 13: 317-325,  (1986)

•    Sheikhnejad G and Srivastava PN.  Isolation and Properties of a Phosphatidylcholine Specific Phospholipase C from Bull Seminal Plasma.
            JBC; 261: 7544-7549, (1986)

•    Sheikhnejad G. and Srivastava, P.N. The Purification of Phospholipase C and its Role in Sperm Acrosomal Reaction; 13th International Congress of Biochemistry in Amsterdam, Holland;  (1985)

•    Rahi H, Sheikhnejad G and Srivastava PN. Isolation of the Inner-Acrosomal Membrane Complex from Rabbit Spermatozoa. Gamete Res.; 7: 215-226,  (1983)
 

Reza Sheikhnejad, ProNAi Therapeutics ProNAi raising vc for phase two